Gartanin

Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells[1][2].

Product Specifications

CAS Number

[33390-42-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Autophagy; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gartanin.html

Purity

98.55

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=C(OC3=C(O)C=CC(O)=C13)C(C/C=C(C)\C)=C(O)C(C/C=C(C)/C)=C2O

Molecular Formula

C23H24O6

Molecular Weight

396.43

Precautions

H302, H315, H319

References & Citations

[1]Gao XY, et al. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochem Res. 2016 Sep;41 (9) :2267-77.|[2]Kim MO, et al. Gartanin induces autophagy through JNK activation which extenuates caspase-dependent apoptosis. Oncol Rep. 2015 Jul;34 (1) :139-46.