MAGL-IN-1

MAGL-IN-1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL-IN-1 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL-IN-1 blocks MAGL in cell-based as well as in vivo assays[1].

Product Specifications

CAS Number

[2324160-91-8]

UNSPSC

12352005

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MAGL-IN-1.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(C1CCN(C(C2=CC(O)=CC=C2F)=O)CC1)C3=CC=C(C(C)C)C=C3

Molecular Formula

C22H24FNO3

Molecular Weight

369.43

References & Citations

[1]Granchi C, et al. Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. J Med Chem. 2019 Feb 28;62 (4) :1932-1958.