Usmarapride (free base)
Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM) . Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].
Product Specifications
CAS Number
[1428862-32-1]
Product Name Alternative
SUVN-D4010 (free base)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/usmarapride-free-base.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(N1N=C(C2=NN=C(C3CCN(CCCOC)CC3)O2)C4=C1C=CC=C4)C
Molecular Formula
C21H29N5O2
Molecular Weight
383.49
References & Citations
[1]Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010) : A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64 (15) :10641-10665.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Apolipoprotein D
Available Sizes
Curated Selection
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