Usmarapride (free base)

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM) . Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

Product Specifications

CAS Number

[1428862-32-1]

Product Name Alternative

SUVN-D4010 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/usmarapride-free-base.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(N1N=C(C2=NN=C(C3CCN(CCCOC)CC3)O2)C4=C1C=CC=C4)C

Molecular Formula

C21H29N5O2

Molecular Weight

383.49

References & Citations

[1]Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010) : A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64 (15) :10641-10665.