(S, R, S) -AHPC-amido-C7-acid

(S, R, S) -AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S, R, S) -AHPC-amido-C5-acid can be used to design PROTACs[1].

Product Specifications

CAS Number

[2172819-76-8]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-amido-c7-acid.html

Purity

98.71

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(CCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)=O

Molecular Formula

C31H44N4O6S

Molecular Weight

600.77

References & Citations

[1]Sun N, et al. Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. J Med Chem. 2023 Jan 12;66 (1) :596-610.