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LBT-999

LBT-999 is a phenyltropane derivative used for positron emission tomography (PET) exploration of the dopamine transporter (DAT) . It has high affinity binding to DAT on rat striatal membranes and human postmortem brain slices in vitro, high uptake in the striatum in rat and baboon models in vivo, and its binding can be blocked by specific compounds.

Product Specifications

CAS Number

877467-20-4

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lbt-999.html

Smiles

COC([C@@H]1[C@]2([H])N([C@](CC2)([H])C[C@@H]1C3=CC=C(C=C3)C)C/C=C/CF)=O

Molecular Formula

C20H26FNO2

Molecular Weight

331.42

References & Citations

[1]Pharmacological characterization of (E) -N- (4-fluorobut-2-enyl) -2beta-carbomethoxy-3beta- (4'-tolyl) nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Frequently Asked Questions

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