GSK-3b Inhibitor XI

GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a Ki value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease[1].

Product Specifications

CAS Number

[626604-39-5]

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-3b-inhibitor-xi.html

Purity

99.10

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

O=C(C(C1=CN(CCCO)C2=NC=CC=C21)=C3C4=NC=CN=C4)NC3=O

Molecular Formula

C18H15N5O3

Molecular Weight

349.34

References & Citations

[1]O'Neill, et al. Design, synthesis, and biological evaluation of novel 7-azaindolylheteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors. Bioorg. Med. Chem. 12 (12), 3167-3185 (2004) .