GSK-3b Inhibitor XI
GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a Ki value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease[1].
Product Specifications
CAS Number
[626604-39-5]
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3b-inhibitor-xi.html
Purity
99.10
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
O=C(C(C1=CN(CCCO)C2=NC=CC=C21)=C3C4=NC=CN=C4)NC3=O
Molecular Formula
C18H15N5O3
Molecular Weight
349.34
References & Citations
[1]O'Neill, et al. Design, synthesis, and biological evaluation of novel 7-azaindolylheteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors. Bioorg. Med. Chem. 12 (12), 3167-3185 (2004) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
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