5HPP-33
5HPP-33 is an inhibitor for tubulin polymerization with IC50 of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC50 of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis[1][2].
Product Specifications
CAS Number
105624-86-0
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5hpp-33.html
Smiles
O=C1C2=CC=C(C=C2C(N1C3=C(C(C)C)C=CC=C3C(C)C)=O)O
Molecular Formula
C20H21NO3
Molecular Weight
323.39
Precautions
P273-P391-P501
References & Citations
[1]Inatsuki S, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005 Jan 17;15 (2) :321-5. |[2]Iguchi T, et al. 5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells[J]. Blood, 2005, 106 (11) : 1586.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL314398 1 Kit
C10orf72 (VSTM4) Human shRNA Plasmid Kit (Locus ID 196740)
Sign In for Pricing
View Details 
NB100-65865 0.1 mg
Armenian Hamster Monoclonal IL-1 RI Antibody (JAMA-147)
Sign In for Pricing
View Details 
