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Antifungal agent 122

Antifungal agent 122 (compound 201) is a potent and broad-spectrum antifungal agent. Antifungal agent 122 prevents fungal phase transition and the formation of fungal biofilm. Antifungal agent 122 inhibits CYP3A4-M and CYP3A4-T enzyme activity with IC50 values of 2.11, 4.53 µM. Antifungal agent 122 shows no cytotoxicity[1].

Product Specifications

CAS Number

[3054212-80-2]

UNSPSC

12352005

Target

Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antifungal-agent-122.html

Smiles

FC1=CC=C([C@@]([C@H](N(C)CC2=CC=C(C#CC3=CC=C(F)C=C3F)C=C2)C)(O)CN4N=CN=C4)C(F)=C1

Molecular Formula

C28H24F4N4O

Molecular Weight

508.51

References & Citations

[1]Sun Y, et al. Discovery of highly potent triazole derivatives with broad-spectrum antifungal activity based on Iodiconazole. Eur J Med Chem. 2024 Oct 9;280:116949.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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