NW-1172 (free base)
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.
Product Specifications
CAS Number
911290-20-5
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nw-1172-free-base.html
Smiles
O=C1C=C(CNC)C2=CC=C(OCC3=CC=CC(Cl)=C3)C=C2O1
Molecular Formula
C18H16ClNO3
Molecular Weight
329.78
References & Citations
[1]Pisani L, et al. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[ (3-chlorobenzyl) oxy]-4-[ (methylamino) methyl]-2 H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor[J]. Journal of medicinal chemistry, 2009, 52 (21) : 6685-6706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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