LK-60

LK-60 is a potent DprE1 inhibitor. LK-60 effectively inhibits the proliferation of Mycobacterium tuberculosis. LK-60 has good safety profiles to gut microbiota and human cells[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lk-60.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N=C(N2C(NC3=CC=CC(C(F)(F)F)=C3)=CC(C)=N2)NC(CC)=C1

Molecular Formula

C17H16F3N5O

Molecular Weight

363.34

References & Citations

[1]Yang L, et al. Discovery of N- (1- (6-Oxo-1,6-dihydropyrimidine) -pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis. J Med Chem. 2024 Jan 17.