PIP5K1C-IN-1
PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor, with an IC50 of 0.80 nM. PIP5K1C-IN-1 exhibits low total clearance in mice and high levels of kinase selectivity. PIP5K1C-IN-1 can be used for the research of cancer and chronic pain[1].
Product Specifications
CAS Number
[3060954-15-3]
UNSPSC
12352005
Target
PI4P5K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pip5k1c-in-1.html
Purity
98.71
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(C31CCC3)C(C(N4)=CC5=C4C=C(Cl)C=C5)=NN2)NC6CC6
Molecular Formula
C20H20ClN5O
Molecular Weight
381.86
References & Citations
[1]Ochiai K, et al. Discovery of Novel Bicyclic Pyrazoles as Potent PIP5K1C Inhibitors. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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