GARP&Latent TGF beta Complex, Mouse (Biotinylated, HEK293, His-Avi)

GARP/latent TGF-b1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein (GARP (I18-N628) &TGF-b1 (L30-S390) ) produced by HEK293 cells with His-Avi tag[1][2].

Product Specifications

Product Name Alternative

GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/garp-latent-tgf-beta-complex-protein-mouse-biotinylated-hek293-his-avi.html

Purity

95.00

Molecular Formula

434215&21803 (Gene_ID) G3XA59 (I18-N628) &P04202 (L30-S390) (Accession)

Molecular Weight

72-76 kDa (GARP), 13 kDa and 45-47 kDa (Latent TGF beta 1)

References & Citations

[1]Soyoung A Oh, TGF-β: guardian of T cell function. J Immunol. 2013 Oct 15;191 (8) :3973-9.|[2]Angela X Zhou, et al. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013 May 15;190 (10) :5057-64.|[3]Justin P Edwards, et al. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. Eur J Immunol. 2016 Jun;46 (6) :1480-9.