Triadimefon
Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory[1][2][3][4][5][6][7].
Product Specifications
CAS Number
43121-43-3
UNSPSC
12352005
Hazard Statement
H302, H317, H330, H400, H411
Target
Akt; AMPK; Fungal; PERK
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection; Endocrinology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/triadimefon.html
Purity
98.12
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(C)(C(C(N1N=CN=C1)OC2=CC=C(C=C2)Cl)=O)C
Molecular Formula
C14H16ClN3O2
Molecular Weight
293.75
Precautions
H302, H317, H330, H400, H411
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1
Available Sizes
Frequently Asked Questions
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