Triadimefon

Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[43121-43-3]

UNSPSC

12352005

Hazard Statement

H302, H317, H330, H400, H411

Target

Akt; AMPK; Fungal; PERK

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Endocrinology; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/triadimefon.html

Purity

98.12

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C)(C(C(N1N=CN=C1)OC2=CC=C(C=C2)Cl)=O)C

Molecular Formula

C14H16ClN3O2

Molecular Weight

293.75

Precautions

H302, H317, H330, H400, H411

References & Citations

[1]Kong Z, et al. The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism. Sci Rep. 2016 Sep 15;6:33552.|[2]Xu Q, et al. Triadimefon suppresses fetal adrenal gland development after in utero exposure. Toxicology. 2021 Oct;462:152932. |[3]Iyer V V, et al. Effects of Triadimefon on the Metabolism of Cultured Hepatocytes[C]//2010 IEEE International Conference on BioInformatics and BioEngineering. IEEE, 2010: 118-123. |[4]Walker QD, et al. Triadimefon and triadimenol: effects on monoamine uptake and release. Toxicol Appl Pharmacol. 1996 Aug;139 (2) :227-33.|[5]Lin L, et al. Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure. Ecotoxicol Environ Saf. 2021 Oct 30;228:112942. |[6]Di Renzo F, et al. Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse. Reprod Toxicol. 2011 Feb;31 (2) :194-9. |[7]Xi J, et al. Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats. Behav Pharmacol. 2012 Dec;23 (8) :727-34.