Adenosine receptor antagonist 5
Adenosine receptor antagonist 5 (Compound 39) is a selective antagonist for human adenosine A3 receptor (hA3R) with Ki of 12 nM. Adenosine receptor antagonist 5 inhibits IB-MECA -induced cAMP accumulation in NCI-H1792 cell, inhibits the proliferation of cancer cell LK-2 and NCI-H1792. Adenosine receptor antagonist 5 exhibits a fast metabolic rate in human liver microsomes[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adenosine-receptor-antagonist-5.html
Smiles
CC1=C(C(C2=C(C=CC=C2Cl)Cl)=NO1)C(O/N=C(C3=CC=C(C=N3)Br)\N)=O
Molecular Formula
C17H11BrCl2N4O3
Molecular Weight
470.10
References & Citations
[1]Huang X, et al., Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor. J Med Chem. 2024 Aug 8;67 (15) :13117-13146.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)
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