PG106 (TFA)

PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].

Product Specifications

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pg106-tfa.html

Purity

98.13

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C(F)(F)F)O.CCCC[C@@H](C(N[C@H]1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](NC([C@@H](NC([C@H](NC(CCNC1=O)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CCCNC(N)=N)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)NC(C)=O

Molecular Formula

C53H70F3N13O11

Molecular Weight

1122.20

References & Citations

[1]Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides