PG106 (TFA)
PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].
Product Specifications
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pg106-tfa.html
Purity
98.13
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(F)(F)F)O.CCCC[C@@H](C(N[C@H]1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](NC([C@@H](NC([C@H](NC(CCNC1=O)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CCCNC(N)=N)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)NC(C)=O
Molecular Formula
C53H70F3N13O11
Molecular Weight
1122.20
References & Citations
[1]Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC3R
Available Sizes
Curated Selection
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