What is the catalog number for MB21D1 Antibody [AMM02560G]?

The catalog number for MB21D1 Antibody [AMM02560G] is AMM02560G.

What sizes are available for MB21D1 Antibody [AMM02560G]?

MB21D1 Antibody [AMM02560G] is available in the following size(s): 50 µL, 100 µL, 200 µL, 400 µL.

How many pack sizes does MB21D1 Antibody [AMM02560G] come in?

MB21D1 Antibody [AMM02560G] is available in 4 different pack sizes.

Is MB21D1 Antibody [AMM02560G] in stock?

MB21D1 Antibody [AMM02560G] is currently made to order / not held in immediate stock. Contact us for lead time.

MB21D1 Antibody [AMM02560G]

Product Specifications

Background

Tissue Location: Expressed in the monocytic cell line THP1.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MB21D1 Antibody [AMM02560G].

Synonyms

Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, 2.7.7.86, Mab-21 domain-containing protein 1, MB21D1, C6orf150

Gene Name

CGAS {ECO:0000303|PubMed:23258413, ECO:0000312|HGNC:HGNC:21367}

Gene ID

115004

UniProt

Q8N884

Chromosomal Location

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Nucleus. Note=In resting conditions, localizes at the cell membrane as a peripheral membrane protein by binding to phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) (PubMed:30827685) . Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685) . Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (PubMed:30827685) . Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubMed:26048138) . Phosphorylation at Tyr-215 promotes cytosolic retention; translocates into the nucleus following dephosphorylation (PubMed:30356214) .

Applications

Dilution

WB--1:1000

Function

232584132370706123722159240771002513199029976794307990392836390828214358283639082836390828314590300074163000741628363908239299452604643726048138240771002622911528738408287598892873840828759889287384082875988930356214

Molecular Weight

58814

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.