ATP-d14 (dilithium)

ATP-d14 (Adenosine 5'-triphosphate-d14) dilithium is deuterium labeled ATP (HY-B2176) . ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

Product Specifications

Product Name Alternative

Adenosine 5'-triphosphate-d14 (dilithium)

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Concentration

100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5

Purity

99.30

Solubility

10 mM in DMSO

Smiles

O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@](N2C3=NC([2H])=NC(N([2H])[2H])=C3N=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O

Molecular Formula

C10D14Li2N5O13P3

Molecular Weight

533.13

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35 (3) :852-8.|[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112 (2) :358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8 (5) : e63759.