EGFR Antibody [AMM02493G]
Product Specifications
Background
Tissue Location: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EGFR Antibody [AMM02493G].
Synonyms
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Gene Name
HGNC:3236
Gene ID
1956
UniProt
P00533
Chromosomal Location
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein Endosome Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029) . Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029) . Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055)
Applications
WB, IHC-P, FC
Dilution
FC--1:25 IHC-P--1:100~500 WB--1:2000
Form
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
27909601080572527153536279096076791048144591941997515611079122970492715353620837704179090292715353611116146116026041148358920462955
Molecular Weight
134277
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1956
Uniprot URL
https://www.uniprot.org/uniprot/P00533
Available Sizes
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