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ERCC1 Antibody (C-term) [AMM02449G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ERCC1 Antibody (C-term) [AMM02449G].

Synonyms

DNA excision repair protein ERCC-1, ERCC1

Gene Name

ERCC1

Gene ID

2067

UniProt

P07992

Chromosomal Location

[Isoform 1]: Nucleus [Isoform 3]: Nucleus

Applications

WB

Dilution

WB--1:2000

Form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Function

[Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL) . Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Molecular Weight

32562

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=2067

Uniprot URL

https://www.uniprot.org/uniprot/P07992

Available Sizes

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