MVP Antibody (N-term) (Ascites) [AMM02437G]

Product Specifications

Background

Tissue Location: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug- resistant cancer cells

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MVP Antibody (N-term) (Ascites) [AMM02437G].

Synonyms

Major vault protein, MVP, Lung resistance-related protein, MVP, LRP

Gene Name

MVP

Gene ID

9961

UniProt

Q14764

Chromosomal Location

Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037) . Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665)

Applications

Dilution

WB--1:100~1600

Form

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.