CYP3A4-IN-4
Product Specifications
UNSPSC Description
CYP3A4-IN-4 (compound Δ,Λ-3), a Ru(II)−Ir(III) Conjugate, is a photoactive inhibitor of the major human drug metabolizing enzyme CYP3A4. CYP3A4-IN-4 containing the [Ru(tpy)(Me2bpy)] photocaging group showed an IC50 of 2.2 μM for inhibition of microsomal CYP3A4 under light conditions (λirr=530 nm, tirr=15 min). CYP3A4-IN-4 shows the phototherapeutic index (PI) for of 5.4[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp3a4-in-4.html
Smiles
O=C(CCC1=CC=[N]([Ru+2]23([N]4=C5C=CC=C4C6=CC=CC=[N]62)([N]7=C(C)C=CC=C7C8=CC=CC(C)=[N]83)[N]9=C5C=CC=C9)C=C1)NCC%10=C[N]%11=C(C%12=[N]([Ir+]%13%14(C%15=C(C%16=[N]%14C(C=CC=C%17)=C%17C=C%16)SC%18=C%15C=CC=C%18)%11C%19=C(C%20=[N]%13C(C=CC=C%21)=C%21C=C%20)SC%22=C%19C=CC=C%22)C=CC=C%12)C=C%10.[Cl-].[Cl-].[Cl-]
Molecular Weight
1656.19
References & Citations
[1]Justin J Ahrens, et al. Mixed Ru(II)-Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. Inorg Chem. 2024 Oct 7;63(40):18509-18518.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169217/CYP3A4-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169217/
Clinical Information
No Development Reported
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