C-Fms-IN-3
C-Fms-IN-3 is an orally active c-Fms (CSF1R) kinase inhibitor (IC50 = 0. 8 nM). c-Fms-IN-3 inhibits CSF1R kinase activity and reduces macrophage populations. c-Fms-IN-3 reduces bone erosion, pannus invasion, cartilage damage, and inflammation in collagen -induced arthritis mouse model. c-Fms-IN-3 is useful for arthritis research[1][2].
Product Specifications
CAS Number
885704-21-2
UNSPSC
12352005
Target
C-Fms; c-Kit; FLT3; TAM Receptor; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/c-FMS-inhibitor.html
Purity
99.69
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN(CC1)CCN1C2=CC=C(NC(C3=CC(C#N)=CN3)=O)C(N4CCC(C)CC4)=C2
Molecular Formula
C23H30N6O
Molecular Weight
406.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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