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C-Fms-IN-3

C-Fms-IN-3 is an orally active c-Fms (CSF1R) kinase inhibitor (IC50 = 0. 8 nM). c-Fms-IN-3 inhibits CSF1R kinase activity and reduces macrophage populations. c-Fms-IN-3 reduces bone erosion, pannus invasion, cartilage damage, and inflammation in collagen -induced arthritis mouse model. c-Fms-IN-3 is useful for arthritis research[1][2].

Product Specifications

CAS Number

885704-21-2

UNSPSC

12352005

Target

C-Fms; c-Kit; FLT3; TAM Receptor; Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c-FMS-inhibitor.html

Purity

99.69

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN(CC1)CCN1C2=CC=C(NC(C3=CC(C#N)=CN3)=O)C(N4CCC(C)CC4)=C2

Molecular Formula

C23H30N6O

Molecular Weight

406.52

References & Citations

[1]Meegalla, Sanath K.; Wall, Mark J.; Chen, Jinsheng et al. Structure-based optimization of a potent class of arylamide FMS inhibitors. Bioorganic & Medicinal Chemistry Letters (2008), 18 (12), 3632-3637.|[2]Illig, Carl R.; Chen, Jinsheng; Wall, Mark J. et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters (2008), 18 (5), 1642-1648.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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