PROTAC SMARCA2 degrader-31
PROTAC SMARCA2-degrader-36 (compound 38) is a SMARCA2 degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer (Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand ; Black, linker HY-W014125).
Product Specifications
CAS Number
2380274-45-1
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-31.html
Smiles
OC1=C(C2=CC(N3CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=C(N)N=N2)C=CC=C1
Molecular Formula
C48H65N9O6S
Molecular Weight
896.15
References & Citations
[1]Sanjita SASMAL, et al. Pyridazine derivatives as smarca2/4 degraders. WO2019207538 A1. 2024-03-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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