JMV6944
Product Specifications
CAS Number
[2871774-93-3]
UNSPSC Description
JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704)[1].
Target Antigen
Cytochrome P450; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jmv6944.html
Smiles
O=S(NC1=CC=C(N(CC2=CC=CC=C2)C(CCCCCCCN)=N3)C3=C1)(C4=C(C)C=C(C)C=C4C)=O
Molecular Weight
518.71
References & Citations
[1]Bansard L, et al. A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse[J]. 2024.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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