H-1152 (dihydrochloride)
H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
Product Specifications
CAS Number
871543-07-6
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/H-1152-dihydrochloride.html
Purity
99.47
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 35.71 mg/mL (ultrasonic)
Smiles
CC1=CN=CC2=C1C(S(=O)(N3[C@@H](C)CNCCC3)=O)=CC=C2.[H]Cl.[H]Cl
Molecular Formula
C16H23Cl2N3O2S
Molecular Weight
392.34
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2
Citation 01
Research Square Preprint. 2021 Jun.|University of Toronto. 2026.|Acta Neuropathol Commun. 2024 Sep 14;12 (1) :150.|bioRxiv. 2025 May 09.
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