H-1152 (dihydrochloride)

H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.

Product Specifications

CAS Number

[871543-07-6]

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/H-1152-dihydrochloride.html

Purity

99.47

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 35.71 mg/mL (ultrasonic)

Smiles

CC1=CN=CC2=C1C(S(=O)(N3[C@@H](C)CNCCC3)=O)=CC=C2.[H]Cl.[H]Cl

Molecular Formula

C16H23Cl2N3O2S

Molecular Weight

392.34

References & Citations

[1]Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754 (1-2) :245-52. Epub 2005 Sep 12.|[2]Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81 (1) :9-16.|[3]Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169 (2) :855-62.