What is the catalog number for EPHA5 Antibody [APR11861G]?

The catalog number for EPHA5 Antibody [APR11861G] is APR11861G.

What sizes are available for EPHA5 Antibody [APR11861G]?

EPHA5 Antibody [APR11861G] is available in the following size(s): 50 µL, 100 µL, 200 µL, 400 µL.

How many pack sizes does EPHA5 Antibody [APR11861G] come in?

EPHA5 Antibody [APR11861G] is available in 4 different pack sizes.

Is EPHA5 Antibody [APR11861G] in stock?

EPHA5 Antibody [APR11861G] is currently made to order / not held in immediate stock. Contact us for lead time.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

EPHA5 Antibody [APR11861G]

Product Specifications

Background

Tissue Location: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EPHA5 Antibody [APR11861G].

Synonyms

Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EHK-1, EPH-like kinase 7, EK7, hEK7, EPHA5, BSK, EHK1, HEK7, TYRO4

Gene Name

EPHA5

Gene ID

2044

UniProt

P54756

Chromosomal Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite

Applications

WB, IHC-P

Dilution

WB--1:2000 IHC-P--1:100~500

Form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity) .