FGA Antibody (N-term) [AMM04535G]
Product Specifications
Background
Tissue Location: Detected in blood plasma (at protein level) .
Synonyms
Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
Gene Name
FGA
Gene ID
2243
UniProt
P02671
Chromosomal Location
Secreted
Applications
WB
Dilution
WB--1:1000 WB--1:500~1000
Form
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Function
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Molecular Weight
94973
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGA Antibody (N-term) [AMM04535G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2243
Uniprot URL
https://www.uniprot.org/uniprot/P02671
Available Sizes
Curated Selection
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