L-Homocysteine thiolactone (hydrochloride)

L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice[1][2][3].

Product Specifications

CAS Number

[31828-68-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/L-Homocysteine_thiolactone_hydrochloride.html

Purity

99.99

Solubility

DMSO : 116.67 mg/mL (ultrasonic) |H2O : ≥ 23 mg/mL

Smiles

N[C@@H](CCS1)C1=O.Cl

Molecular Formula

C4H8ClNOS

Molecular Weight

153.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Jakubowski H, et al. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000 Feb;130 (2S Suppl) :377S-381S.|[2]Ahmed S Ibrahim, et al. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget. 2016 Feb 23;7 (8) :8532-45.|[3]Nehal M Elsherbiny, et al. Homocysteine Induces Inflammation in Retina and Brain. Biomolecules. 2020 Mar 3;10 (3) :393. |[4]Olivera Stanojlović, et al. Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study. Cell Mol Neurobiol. 2009 May;29 (3) :329-39.