PARK8 (LRRK2) Antibody [APR14064G]
Product Specifications
Background
Tissue Location: Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level) . Expressed in neutrophils (at protein level) (PubMed:29127255) . Expressed in the brain. Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
Synonyms
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Gene Name
LRRK2
Gene ID
120892
UniProt
Q5S007
Chromosomal Location
Cytoplasmic vesicle. Perikaryon. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Endosome {ECO:0000250|UniProtKB:Q5S006}. Lysosome Mitochondrion outer membrane; Peripheral membrane protein Note=Colocalized with RAB29 along tubular structures emerging from Golgi apparatus (PubMed:23395371) . Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882) .
Applications
WB
Dilution
WB--1:2000 IHC--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
209490422201298526824392291254622872071829127255303981482921281530635421218506872339537117114044246878522601438525201882268243922872071829127255303981482921281529125462306354212682439228720718291272553039814829212815291254623063542123395371268243922682439229125462303981482339537117114044246878522520188222012985220129852185068728720718260143851823073526824392291254622872071829212815
Molecular Weight
286103
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PARK8 (LRRK2) Antibody [APR14064G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=120892
Uniprot URL
https://www.uniprot.org/uniprot/Q5S007
Available Sizes
Curated Selection
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