CD31 (TFA)

CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB) . CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation[1]-[5].

Product Specifications

Product Name Alternative

PECAM-1 (TFA)

UNSPSC

12352209

Target

Bacterial; SHP2

Type

Peptides

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cd31-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.O=C([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)CC4=CNC5=CC=CC=C45

Molecular Formula

C121H203F3N36O31

Molecular Weight

2715.12

References & Citations

[1]Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115 (9) :1425-1434.|[2]Ling V, et al. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31) . Eur J Immunol. 1997 Feb. 27 (2) :509-14.|[3]Bruggisser J, et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020 Jul 8. 28 (1) :69-78.e6.|[4]Caligiuri G. CD31 as a Therapeutic Target in Atherosclerosis. Circ Res. 2020 Apr 24. 126 (9) :1178-1189. |[5]Fornasa G, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010 May 15. 184 (10) :5485-92.