Anti-Nav1.7 Na+ Channel Antibody

Mouse Monoclonal Antibody specific to Nav1.7 Na+ Channel

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit α, Voltage-gated sodium channel subunit α Nav1.7

Gene Name

SCN9A

NCBI Gene ID

UniProt

Q15858

Accession Number

NP_002968.1

Cellular Locus

Cell membrane, Cell projection, neuron projection

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein, aa 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (accession no. Q15858).

Target Antigen

Sodium channel protein type 9 subunit α

Target

Nav1.7 Na+ Channel

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, ICC/IF, IP, AM

Field of Research

Ion Channels

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). {PubMed:15178348, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784, PubMed:25240195, PubMed:26680203, PubMed:7720699}.

Additionnal Information

Immunoblotting: use at 1ug/mL Immunohistochemistry: use at 1ug/mL These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human, mouse, and rat Nav1.7. It does not cross-react with other Nav channels.

Formulation

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Nav1.7 is a voltage-gated sodium channel that plays an important role in the generation and conduction of action potentials making it important for electrical signaling by most excitable cells. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not directly affect those cells.