D- (KLAKLAK) 2, Proapoptotic Peptide

D- (KLAKLAK) 2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d- (KLAKLAK) 2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d- (KLAKLAK) 2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death) [1].

Product Specifications

CAS Number

[721397-24-6]

UNSPSC

12352209

Target

Apoptosis; Bacterial

Type

Peptides

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/d-klaklak-2-proapoptotic-peptide.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H](N)CCCCN)N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C

Molecular Formula

C72H139N21O14

Molecular Weight

1523.01

References & Citations

[1]Jaber S, et al. Synthesis, antitumor and antibacterial studies of new shortened analogues of (KLAKLAK) 2-NH2 and their conjugates containing unnatural amino acids[J]. Molecules, 2021, 26 (4) : 898.