d-(KLAKLAK)2, Proapoptotic Peptide

d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death)[1].

O=C([C@H](N)CCCCN)N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C

[1]Jaber S, et al. Synthesis, antitumor and antibacterial studies of new shortened analogues of (KLAKLAK) 2-NH2 and their conjugates containing unnatural amino acids[J]. Molecules, 2021, 26(4): 898.