HSP90-IN-33
HSP90-IN-33 (compound 24e) is a potent Hsp90 inhibitor with Kd values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-33.html
Smiles
O=C(C1=C(Cl)C(Cl)=C(C)N1)NC2=CC=C(C(N)=O)C=C2N3CC4(CN(C)CC4)CC3
Molecular Formula
C21H25Cl2N5O2
Molecular Weight
450.36
References & Citations
[1]Dernovšek J, et al. Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders. Eur J Med Chem. 2024 Oct 5;280:116934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
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