Tubulin polymerization-IN-68
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].
Target Antigen
Apoptosis; Caspase; Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-68.html
Smiles
O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
Molecular Weight
263.29
References & Citations
[1]Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163983/Tubulin-polymerization-IN-68-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163983/
Clinical Information
No Development Reported
CAS Number
2924156-96-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
