Tubulin polymerization-IN-68

Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].

Product Specifications

CAS Number

[2924156-96-5]

UNSPSC

12352005

Target

Apoptosis; Caspase; Microtubule/Tubulin; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-68.html

Smiles

O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4

Molecular Formula

C16H13N3O

Molecular Weight

263.29

References & Citations

[1]Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4 (1H) -one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation