Tubulin polymerization-IN-68
Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].
Product Specifications
CAS Number
2924156-96-5
UNSPSC
12352005
Target
Apoptosis; Caspase; Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-68.html
Smiles
O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
Molecular Formula
C16H13N3O
Molecular Weight
263.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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