S100B Antibody [APR05455G]
Product Specifications
Background
Tissue Location: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues
Synonyms
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B
Gene Name
S100B
Gene ID
6285
UniProt
P04271
Chromosomal Location
Cytoplasm. Nucleus
Applications
WB, IHC-P-Leica, FC
Dilution
IHC-P-Leica--1:500 WB--1:2000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Molecular Weight
10713
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality S100B Antibody [APR05455G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6285
Uniprot URL
https://www.uniprot.org/uniprot/P04271
Available Sizes
Curated Selection
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