Phospho-STAT3 (Y705) Antibody [APR05155G]
Product Specifications
Background
Tissue Location: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4 (+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195)
Synonyms
Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
Gene Name
HGNC:11364
Gene ID
6774
UniProt
P40763
Chromosomal Location
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 Identified in a complex with LYN and PAG1
Applications
WB
Dilution
WB--1:500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
106886511235922512873986151947001734421418242580230844761734421412873986123592251519470028065600173442141824258023084476
Molecular Weight
88068
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-STAT3 (Y705) Antibody [APR05155G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6774
Uniprot URL
https://www.uniprot.org/uniprot/P40763
Available Sizes
Curated Selection
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