POU5F1 Antibody (C-term) [APR04780G]
Product Specifications
Background
Tissue Location: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
Synonyms
POU domain, class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3
Gene Name
POU5F1
Gene ID
5460
UniProt
Q01860
Chromosomal Location
Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. {ECO:0000250|UniProtKB:P20263, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:23024368}
Applications
WB
Dilution
WB--1:1000
Function
Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') . Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Molecular Weight
38571
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality POU5F1 Antibody (C-term) [APR04780G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5460
Uniprot URL
https://www.uniprot.org/uniprot/Q01860
Available Sizes
Curated Selection
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