UBE3C Antibody (Center) [APR04583G]

Product Specifications

Background

Tissue Location: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality UBE3C Antibody (Center) [APR04583G].

Synonyms

Ubiquitin-protein ligase E3C, 632-, HectH2, UBE3C, KIAA0010, KIAA10

Gene Name

UBE3C

Gene ID

9690

UniProt

Q15386

Chromosomal Location

Nucleus.

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys- 48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Molecular Weight

123923

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.