P16INK4a Antibody (C-term E119) [APR03602G]
Product Specifications
Background
Tissue Location: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific
Synonyms
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1
Gene Name
HGNC:1787
Gene ID
1029
UniProt
P42771
Chromosomal Location
Cytoplasm. Nucleus
Applications
WB, FC, IHC-P-Leica
Dilution
IHC-P-Leica--1:500 WB--1:2000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Molecular Weight
16533
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p16INK4a Antibody (C-term E119) [APR03602G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1029
Uniprot URL
https://www.uniprot.org/uniprot/P42771
Available Sizes
Curated Selection
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