P16INK4a Antibody (C-term E119) [APR03602G]

Product Specifications

Background

Tissue Location: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p16INK4a Antibody (C-term E119) [APR03602G].

Synonyms

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1

Gene Name

HGNC:1787

Gene ID

1029

UniProt

P42771

Chromosomal Location

Cytoplasm. Nucleus

Applications

WB, FC, IHC-P-Leica

Dilution

IHC-P-Leica--1:500 WB--1:2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.