NSE4A Antibody (N-term) [APR06212G]
Product Specifications
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NSE4A Antibody (N-term) [APR06212G].
Synonyms
Non-structural maintenance of chromosomes element 4 homolog A, NS4EA, Non-SMC element 4 homolog A, NSMCE4A, C10orf86
Gene Name
NSMCE4A
Gene ID
54780
UniProt
Q9NXX6
Chromosomal Location
Nucleus. Chromosome, telomere
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Is involved in positive regulation of response to DNA damage stimulus.
Molecular Weight
44301
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=54780
Uniprot URL
https://www.uniprot.org/uniprot/Q9NXX6
Available Sizes
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