RNF8 Antibody [APR06201G]
Product Specifications
Background
Tissue Location: Ubiquitous. In fetal tissues, highest expression in brain, thymus and liver. In adult tissues, highest levels in brain and testis, lowest levels in peripheral blood cells
Synonyms
E3 ubiquitin-protein ligase RNF8, hRNF8, 632-, RING finger protein 8, RNF8, KIAA0646
Gene Name
RNF8 {ECO:0000255|HAMAP-Rule:MF_03067}
Gene ID
9025
UniProt
O76064
Chromosomal Location
Nucleus {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:14981089, ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:23233665}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03067}. Midbody {ECO:0000255|HAMAP- Rule:MF_03067}. Chromosome, telomere {ECO:0000255|HAMAP-Rule:MF_03067} Note=Recruited at uncapped telomeres (By similarity) . Following DNA damage, such as double-strand breaks, recruited to the sites of damage (PubMed:18001824, PubMed:18077395, PubMed:22266820, PubMed:23233665) During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1 {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:22266820, ECO:0000269|PubMed:23233665}
Applications
WB, FC
Dilution
WB--1:1000 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by protein affinity purification.
Function
11322894149810891772446018001824180018251800670518077395183372451894875619015238191244601920206119203578192035792055093321558560218576712191136022266820223735792253178222705371228654502298097923233665113228941498108917724460180018241800182518006705180773951833724518948756190152381912446019202061192035781920357920550933215585602185767121911360222668202237357922531782227053712286545022980979
Molecular Weight
55518
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RNF8 Antibody [APR06201G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=9025
Uniprot URL
https://www.uniprot.org/uniprot/O76064
Available Sizes
Curated Selection
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