ACK1 Antibody (C-term) [APR05996G]

Product Specifications

Background

Tissue Location: The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ACK1 Antibody (C-term) [APR05996G].

Synonyms

Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1

Gene Name

TNK2

Gene ID

10188

UniProt

Q07912

Chromosomal Location

Cell membrane. Nucleus. Endosome {ECO:0000250|UniProtKB:O54967} Cell junction, adherens junction. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle Membrane, clathrin-coated pit. Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity) . Co-localizes with EGFR on endosomes (PubMed:20333297) . Nuclear translocation is CDC42-dependent (By similarity) . Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity) {ECO:0000250|UniProtKB:O54967, ECO:0000269|PubMed:20333297}

Applications

IHC-P, WB

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.