What is the catalog number for ERBB2 Antibody (C-term Y1248) [APR05967G]?

The catalog number for ERBB2 Antibody (C-term Y1248) [APR05967G] is APR05967G.

What sizes are available for ERBB2 Antibody (C-term Y1248) [APR05967G]?

ERBB2 Antibody (C-term Y1248) [APR05967G] is available in the following size(s): 50 µL, 100 µL, 200 µL, 400 µL.

How many pack sizes does ERBB2 Antibody (C-term Y1248) [APR05967G] come in?

ERBB2 Antibody (C-term Y1248) [APR05967G] is available in 4 different pack sizes.

Is ERBB2 Antibody (C-term Y1248) [APR05967G] in stock?

ERBB2 Antibody (C-term Y1248) [APR05967G] is currently made to order / not held in immediate stock. Contact us for lead time.

ERBB2 Antibody (C-term Y1248) [APR05967G]

Product Specifications

Background

Tissue Location: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ERBB2 Antibody (C-term Y1248) [APR05967G].

Synonyms

Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL

Gene Name

ERBB2

Gene ID

2064

UniProt

P04626

Chromosomal Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794) . [Isoform 3]: Cytoplasm. Nucleus.

Applications

WB, IHC-P

Dilution

WB--1:1000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs) . Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.