NEK8 Antibody (C-term) [APR05843G]
Product Specifications
Background
Tissue Location: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma
Synonyms
Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nima-related protein kinase 12a, NEK8, JCK, NEK12A
Gene Name
NEK8
Gene ID
284086
UniProt
Q86SG6
Chromosomal Location
Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZR4}. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytoplasmic Localizes to the proximal region of the primary cilium and is not observed in dividing cells. {ECO:0000250|UniProtKB:Q91ZR4}
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity) . Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Molecular Weight
74806
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NEK8 Antibody (C-term) [APR05843G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=284086
Uniprot URL
https://www.uniprot.org/uniprot/Q86SG6
Available Sizes
Curated Selection
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